PHARMACOLOGICAL PROPERTIES OF 3‐PHENYL‐5 β DIETHYLAMINOETHYL‐1,2,4‐OXADIAZOLE

Abstract

The general pharmacological properties of Oxolamine (3-phenyl-5beta-diethylaminoethyl-1,2,4-oxadiazole) are described. The antitussive activity of this drug is more apparent in tests involving a diffuse stimulation of the bronchial tree than with electrical stimulation of the superior laryngeal nerve. These results suggest a predominantly peripheral mechanism of action. Oxolamine also possesses analgesic-anti-inflammatory, local anaesthetic and antispasmodic properties. The acute and chronic toxicities of Oxolamine are low, and the experimental results indicate the absence of side effects. The possibility that the antitussive activity is related to the other pharmacological properties is discussed.