Autoimmune Complement-fixation Reaction in 1,014 Patients

Abstract

, and Mackay and Gajdusek (1958) reported that fixation of complement occurred when sera from certain hospital patients were incubated with simple saline extracts of various human organs. They called this the " autoimmune complement-fixation reaction" (A.I.C.F.). It had no strict organ specificity, and it occurred most often in cases of liver disease, diffuse " collagen " disease, and macroglobulinaemia.