Elevated Levels of 8-iso-Prostaglandin F_2αin Pericardial Fluid of Patients With Heart Failure

Abstract

Pericardial levels of 8-iso-PGF2alpha increase with the functional severity of heart failure and are associated with ventricular dilatation. These data suggest an important role for in vivo oxidant stress on ventricular remodeling and the progression to heart failure.