Involvement of p53 in gemcitabine mediated cytotoxicity and radiosensitivity in breast cancer cell lines

Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial.

Howard A. Burris, Malcolm J. Moore, John Sahl Andersen et al. · Journal of Clinical Oncology · 1997 · 5.9K citations

Medicine, Oncology, Pharmacotherapy +16

p53 is required for radiation-induced apoptosis in mouse thymocytes

Scott W. Lowe, Earlene M. Schmitt, Sallie W. Smith et al. · Nature · 1993 · 2.9K citations

Medicine, Cell Biology, Oncology +14

Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.

P M O'Connor, Joany Jackman, I Bae et al. · PubMed · 1997 · 882 citations

Medicine, Cancer Biology, Molecular Biology +15

Database of p53 gene somatic mutations in human tumors and cell lines.

Monica Hollstein, Kevin P. Rice, Marc S. Greenblatt et al. · PubMed · 1994 · 863 citations

Medicine, Genetics, Molecular Genetics +17

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

Michele Fiscella, Hongliang Zhang, Saijun Fan et al. · Proceedings of the National Academy of Sciences · 1997 · 542 citations

Life Sciences, Cell Biology, Molecular Biology +17