Pharmacology · 2008 · 139 citations · 0 references
PharmacyPharmacologyToxicologyDrug MetabolismHepatotoxicologyChemical-induced HepatotoxicityHepatic Drug MetabolismHepatic MetabolismHepatic NecrosisHepatic PathophysiologyHepatotoxicity MechanismsAcute Hepatic NecrosisBenzene MetabolismDrug-induced Hepatic NecrosisHepatotoxic MechanismsPolycyclic Aromatic Hydrocarbon Hepatotoxicity
Treatment of rats with Phenobarbital stimulates the metabolism of bromobenzene and potentiates the hepatic necrosis elicited by the hydrocarbon. In contrast, administration of SKF 525-A or of piperonyl butoxide blocks bromobenzene metabolism and prevents the damage to the liver. These results indicate that the hepatotoxic effect of bromobenzene is mediated by a metabolite.