Solid‐Phase Synthesis of Biphenyls and Terphenyls by the Traceless Multifunctional Cleavage of Polymer‐Bound Arenesulfonates

Abstract

Abstract Nickel‐catalyzed reactions between polymer‐bound arenesulfonates and aryl Grignard reagents produce unfunctionalized biphenyls and terphenyls in good yields through reductive cleavage/cross‐coupling of the C–S bond. This novel traceless multifunctional cleavage strategy appears to be a powerful tool for the preparation of large oligophenyl libraries, because it allows the introduction of diversity concomitantly with the release of the target compounds. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)