A Long-term Follow-up Study of 214 Children with the Syndrome of Infantile Spasms

TLDR

The study evaluated the long‑term prognosis of 192 surviving children with infantile spasms. The cohort was recruited from three Helsinki paediatric hospitals, underwent detailed aetiological assessment, received ACTH therapy for approximately six weeks, and was followed up 3–19 years later at the Children’s Hospital, University of Helsinki.

Abstract

The long-term prognosis of 192 surviving children with the syndrome of infantile spasms was evaluated. The children had been admitted to three paediatric hospitals in Helsinki at the time of initial diagnosis. The aetiological factors of the syndrome were carefully studied in each case. ACTH therapy was employed in 162, usually for about six weeks. The follow-up study 3-19 (mean 10.4) years later was made at the Children's Hospital, University of Helsinki.