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Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an α-ketothiazole arginine

Hongfeng Deng, Thomas D. Bannister, Lei Jin, Robert E. Babine, Jesse Quinn, Pamela Nagafuji, Cassandra A. Celatka, Jian Lin, Tsvetelina I. Lazarova, Michael J. Rynkiewicz,

Bioorganic & Medicinal Chemistry Letters · 2006 · 63 citations · 6 references

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References

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Comparison of bleeding tendency, factor XI coagulant activity, and factor XI antigen in 25 factor XI-deficient kindreds

MV Ragni, D Sinha, F S Seaman et al. · Blood · 1985 · 185 citations · Full text

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Factor XI–dependence of surface- and tissue factor–initiated thrombus propagation in primates

András Gruber, Stephen R. Hanson · Blood · 2003 · 149 citations · Full text

, , +16

Roles of Platelets and Factor XI in the Initiation of Blood Coagulation by Thrombin

P. Walsh · Thrombosis and Haemostasis · 2001 · 96 citations

, , +17

Crystal Structures of the FXIa Catalytic Domain in Complex with Ecotin Mutants Reveal Substrate-like Interactions

Lei Jin, Pramod S. Pandey, Robert E. Babine et al. · Journal of Biological Chemistry · 2004 · 58 citations · Full text

, , +16

5-Amidinobenzo[b]thiophenes as dual inhibitors of factors IXa and Xa

Jennifer X. Qiao, Xuhong Cheng, Dilip P. Modi et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 50 citations · Full text

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