TOTAL SYNTHESIS OF (±)-AVENACIOLIDE AND ITS ANALOGUES

Abstract

Abstract A new method for the stereoselective synthesis of (±)-avenaciolide and its analogues via methoxycarbonyl- or anisyloxycarbonyldi-γ-lactones, which could be easily prepared by the reaction of γ-substituted α-bromobutenolides with sodium salt of methyl or anisyl malonamate in good yields, was described.