DNA HYPERMETHYLATION ON MULTIPLE CpG ISLANDS ASSOCIATED WITH INCREASED DNA METHYLTRANSFERASE DNMT1 PROTEIN EXPRESSION DURING MULTISTAGE UROTHELIAL CARCINOGENESIS

Abstract

DNA hypermethylation on multiple CpG islands in association with DNMT1 protein over expression may participate in multistage urothelial carcinogenesis even at the precancerous stage and particularly in the development of nodular invasive carcinomas of the bladder.