Science · 1967 · 210 citations · 19 references
Life SciencesNeurobiologyNeuroscienceNeuroanatomyNeurochemistryNeuropharmacologyCentral Nervous SystemMonoamine NeurochemistryNeurotransmissionNeurotransmitter ReleaseSerotonergic SignalingSynaptic TransmissionMonoamine Release MechanismsRaphe Nucleus SignalingSerotonergic MechanismsSerotonergic ModulationSerotonergic Neuronal PathwaysSerotonergic NeuronsSerotonergic NeurotransmissionSerotonin Release Mechanisms
Electrical stimulation of the midbrain raphé, an area in which neuronal perikarya containing serotonin are aggregated, produces an increase in 5-hydroxyindoleacetic acid and a decrease in serotonin in the forebrain. These changes indicate that serotonin in the brain can be released via a specific neural pathway, namely, the system of axons projecting into the forebrain from serotonin-containing neurons in the midbrain raphé.
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Ascending Monoamine Neurons to the Telencephalon and Diencephalon
N.‐E. Andén, Annica Dahlström, Kjell Fuxé et al. · Acta Physiologica Scandinavica · 1966 · 1.2K citations