Interaction effects of subjective memory impairment and ApoE4 genotype on episodic memory and hippocampal volume

Abstract

The negative effect of ApoE4 on episodic memory and hippocampal volume in SMI supports SMI as a prodromal condition of AD. The positive effects of ApoE4 in subjects without SMI adds to a number of reports on positive ApoE4 effects in young and very old individuals.