Cg Base Pair Recognition Within Dna Triple Helices Using<b><i>N</i></b>-Methyl-3<b><i>H</i></b>-Pyrrolo[2,3-<b><i>d</i></b>]Pyrimidin-2(7<b><i>H</i></b>)-One Nucleoside Analogues

Abstract

Triplex-mediated recognition of Py.Pu base pairs in DNA is a greater challenge than for Pu.Py base pairs as fewer hydrogen bonds are presented for binding in the major groove. Initial studies on m-aminophenyl-modified analogues of the bicyclic nucleoside N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7 H)-one suggest that selective recognition of the CG base pair is possible.