The Autoimmune Response to Vimentin After Renal Transplantation in Nonhuman Primates Is Immunosuppression Dependent

Abstract

We postulate that vimentin acts as an autoantigen after renal transplantation; it elicits an autoimmune response that is not regulated by cyclosporine. This autoimmune response may be part of the complex immunologic events occurring posttransplantation and may contribute to the development of CAN, but cannot be considered as a major cause of CAN because this condition also develops without antivimentin antibodies.