Archives of General Psychiatry · 1975 · 1.5K citations · 68 references
PharmacyPsychologyComparative Effectiveness ResearchOutcomes ResearchPsychotherapyPsychosocial InterventionsTreatment Of Mental DisordersComparative PsychotherapyMultiple TreatmentsPsychotherapy Outcome MeasurementTherapeutic Relationship QualityTie Strength
The authors compiled outcome data from all reasonably controlled comparisons of psychotherapies with each other and with other treatments. Across these studies, psychotherapies generally show no significant differences among themselves, psychopharmacotherapies outperform them, combined treatments outperform single ones, only two patient‑treatment matches were notably beneficial, and common therapeutic components likely explain the overall similarity, suggesting that random assignment may not be warranted.
Tallies were made of outcomes of all reasonably controlled comparisons of psychotherapies with each other and with other treatments. For comparisons of psychotherapy with each other, most studies found insignificant differences in proportions of patients who improved (though most patients benefited). This "tie score effect" did not apply to psychotherapies vs psychopharmacotherapies compared singly—psychopharmacotherapies did better. Combined treatments often did better than single treatments. Among the comparisons, only two specially beneficial matches between type of patient and type of treatment were found. Our explanations for the usual tie score effect emphasize the common components among psychotherapies, especially the helping relationship with a therapist. However, we believe the research does not justify the conclusion that we should randomly assign patients to treatments—research results are usually based on amount of improvement; "amount" may not disclose differences in<i>quality</i>of improvement from each treatment.
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Treatment of Depression by Drugs and Psychotherapy
Gerald L. Klerman, Alberto DiMascio, Myrna M. Weissman et al. · American Journal of Psychiatry · 1974 · 501 citations
Behavior Modification in the Treatment of Obesity
Sydnor B. Penick, Ross D. L. Filion, Sonja Fox et al. · Psychosomatic Medicine · 1971 · 236 citations