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Differential effect of simvastatin on various signal transduction intermediates in cultured human smooth muscle cells11Abbreviations: SMC, smooth muscle cells; S, simvastatin; ERK1/2, extracellular-regulated kinase 1/2; SAPK, stress-activated protein kinase; PDGF, platelet-derived growth factor; PMA, phorbol myristil acetate; POD, peroxydase; MAPK, mitogen-activated protein kinase; TBS, Tris-buffered saline; FPP, farnesyl pyrophosphate; GGPP, geranylgeranyl pyrophosphate; Mev, mevalonic acid lactone, LPA, lysophosphatidic acid; PKC, protein kinase C; GST, glutathione S-transferase; and PAK-CD, p21-activated kinase CRIB domain.