Regulation of Limbal Keratinocyte Proliferation and Differentiation by TAp63 and ΔNp63 Transcription Factors

Abstract

TAp63 and DeltaNp63 affect the proliferation of limbal keratinocytes by a different mechanism. The inhibition by TAp63 antisense oligos appeared to be secondary to the promotion of cell differentiation. In contrast, the inhibition by DeltaNp63 antisense oligos appeared to be independent of cell differentiation.