Concepedia

Synthesis and antitumor activities of 14-O-acyl derivatives of 7-O-(2,6-dideoxy-2-fluoro-.ALPHA.-l-talopyranosyl) adriamycinone.

Tsutomu Tsuchiya, Yasushi Takagi, Sumio Umezawa, TOMIO TAKEUCHI, Keiko Komuro, Chisato Nosaka, HAMAO UMEZAWA, Shunzō Fukatsu, Toshio Yoneta

The Journal of Antibiotics · 1988 · 16 citations · 4 references

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Abstract

Preparation des composes du titre a partir de la bromo-14 O-[didesoxy-2,6 fluoro-2 O-isopropylidene-3,4 α-D-talopyranosyl]-7 daunomycinone et des acides adipique, pimelique, suberique, succinique et glutarique. L'activite antitumorale est etudiee sur des cellules de la lignee L1210 de souris

References

4

N-trifluoroacetyladriamycin-14-valerate, an analog with greater experimental antitumor activity and less toxicity than adriamycin.

Mervyn Israel, Edward J. Modest, Emil Frei · PubMed · 1975 · 129 citations

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Synthesis of antitumor-active 7-O-(2,6-dideoxy-2-fluoro-α-l-talopyranosyl)-daunomycinone and -adriamycinone

O.K. Kwang-dae, Yasushi Takagi, Tsutomu Tsuchiya et al. · Carbohydrate Research · 1987 · 27 citations

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Adriamycin analogs. Rationale, synthesis, and preliminary antitumor evaluation of highly active DNA-nonbinding N-(trifluoroacetyl)adriamycin 14-O-hemiester derivatives

Mervyn Israel, P. G. G. Potti, R. Seshadri · Journal of Medicinal Chemistry · 1985 · 24 citations

, , +14

Syntheses and antitumor activities of 7-O-(2,6-dideoxy-2-fluoro-.ALPHA.-L-talopyranosyl)daunomycinone and -adriamycinone.

Tsutomu Tsuchiya, Yasushi Takagi, Kwang-Dae Ok et al. · The Journal of Antibiotics · 1986 · 21 citations · Full text

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