Expression of Angiogenesis Factors and Selected Vascular Wall Matrix Proteins in Intracranial Saccular Aneurysms

Abstract

These results confirm the gross architectural molecular disruption in the walls of intracranial aneurysms and illustrate an apparent biological response involving angiogenesis factors. Further research should elucidate the time course and possible causal relationships of these changes to aneurysm growth and rupture with the aim of possible therapeutic manipulation.