Sulphasalazine induced selective IgA deficiency in rheumatoid arthritis.

Abstract

and the mean observed peak plasma metoprolol concentration by about 33%. Furthermore, the elimination half life of metoprolol was prolonged from 3-9 hours during monotreatment to 6-0 hours when ranitidine was given in combination (p<0005). There was no evidence that any of the volunteers were poor metabolisers of metoprolol.