PHARMACOLOGICAL STUDIES ON 4 (OR 5)-AMINOIMIDAZOLE-5 (OR 4)-CARBOXAMIDE (AICA) DERIVATIVES

Abstract

In previous works from our laboratory (1-3) we reported that 4-diazoimidazole-5-carboxamide (diazo-ICA) and 4-(mono- or di-substituted) triazenoimidazole-5-carboxamide (mono- or dialkyl-TICA) showed marked inhibitory effects on the growth of tumors and bacterial cells. During examination of their toxicity in mice, behavioral sedation caused by these compounds was also observed (2). These observations led us to investigate the pharmacological properties of these compounds. The present report is on the effects of these compounds on the respiration, blood pressure, peripheral blood vessel and isolated intestine of the rabbit and the electroencephalogram (EEG) and electrocardiogram (EEG) of cats.