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The sigma-1 receptor agonist 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) protects against newborn excitotoxic brain injury by stabilizing the mitochondrial membrane potential in vitro and inhibiting microglial activation in vivo

Microglial ActivationMedicinePharmacologyCell DeathNeuropharmacologyBrain-immune InteractionMitochondrial Membrane PotentialBrain InjuryNeurologyNeuroscienceNeuroprotectionMolecular NeurobiologyNeuroimmunologyNeurochemistrySigma-1 ReceptorOxidative StressNeuroinflammation