Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

Marcy E. MacDonald · Cell · 1993 · 8.4K citations · Full text

Life Sciences, Genetics, Molecular Genetics +13

Neuropathological Classification of Huntingtonʼs Disease

Jean‐Paul Vonsattel, Richard H. Myers, Thomas J. Stevens et al. · Journal of Neuropathology & Experimental Neurology · 1985 · 2.6K citations

Medicine, Neurology, Neuroscience +17

Quinolinic Acid: An Endogenous Metabolite That Produces Axon-Sparing Lesions in Rat Brain

Robert Schwarcz, William O. Whetsell, Richard M. Mangano · Science · 1983 · 1.3K citations

Life Sciences, Neurobiology, Neuroscience +16

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines

Alexander Panov, Claire‐Anne Gutekunst, Blair R. Leavitt et al. · Nature Neuroscience · 2002 · 1K citations

Life Sciences, Genetics, Neurology +13

QUINOLINIC ACID AND KYNURENINE PATHWAY METABOLISM IN INFLAMMATORY AND NON-INFLAMMATORY NEUROLOGICAL DISEASE

Melvyn P. Heyes, Kuniaki Saito, Jeffrey S. Crowley et al. · Brain · 1992 · 684 citations

Life Sciences, Neuroscience, Pharmacology +14