Neuropsychobiology · 1998 · 26 citations · 26 references
Life SciencesGeneticsMolecular GeneticsGenetic EpidemiologyHuman GeneticsMedical GeneticsGenetic Risk FactorsGenetic SusceptibilityGenotype-phenotype Association AnalysisGenotype-phenotype CorrelationCytochrome P450 Genetic PolymorphismCytochrome P450 Genotype Effects
The genotypes of the CYP2E1 loci of 35 alcoholic and 130 nonalcoholic (healthy controls) Japanese were investigated to determine the relationship between CYP2E1 (C/D) polymorphism and susceptibility to alcohol dependence. There was a significant (d.f. = 1, chi2 = 11.0, p < 0.001) difference in the CYP2E1 C gene frequency between alcohol dependents (0.41) and controls (0.28), suggesting that the C gene of CYP2E1 may be related to the risk of developing alcoholism in Japanese, whereas the frequency of the D gene was higher among controls than alcoholics. Healthy Japanese controls showed a significantly (d.f. = 1, chi2 = 30.1, p < 0.001) higher frequency of the C allele than Swedish healthy controls (0. 10) did.
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Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men.
Holly R. Thomasson, Howard J. Edenberg, David W. Crabb et al. · PubMed · 1991 · 625 citations
Distribution of ADH2 and ALDH2 genotypes in different populations
H. W. Goedde, D. P. Agarwal, Gernot Fritze et al. · Human Genetics · 1992 · 569 citations