EXPRESSION AND IMMUNOGENICITY OF ONCOFETAL ANTIGEN-IMMATURE LAMININ RECEPTOR IN HUMAN RENAL CELL CARCINOMA

Abstract

This study demonstrates that OFA-iLR is an immunogenic tumor associated antigen in human renal cell carcinoma. OFA-iLR specific effector T cells producing interferon-gamma may have a role in the control of tumor growth, whereas suppressor T cells producing IL-10 may promote tumor tolerance and, thus, tumor progression.