Publication | Open Access
Synthesis of Extremely Simplified Compounds Possessing the Key Pharmacophore Units of Taxol, Phenylisoserine and Oxetane Moieties.
21
Citations
1
References
1999
Year
Simplified AnaloguesOrganic ChemistryKey Pharmacophore UnitsChemistryPharmaceutical ChemistryMedicinal ChemistryPhenylisoserine UnitExtremely Simplified CompoundsInhibitory ActivityBiochemistryOxetane MoietiesDrug DevelopmentPharmacologyNatural Product SynthesisNatural SciencesStraight Chain CompoundsMedicineDerivative (Chemistry)Synthetic ChemistryDrug Discovery
Straight chain compounds having a phenylisoserine unit and an oxetane ring at the alpha- and omega- position, respectively as extremely simplified analogues of taxol were prepared. None of these compounds showed promising tubulin inhibitory activity.
| Year | Citations | |
|---|---|---|
Page 1
Page 1