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A Constitutive Description of Contracting Papillary Muscle and Its Implications to the Dynamics of the Intact Heart
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1987
Year
Cardiac MuscleHeart FailureSimple Mathematical ModelAnatomyCardiovascular FunctionStructural Heart DiseaseDiastolic FunctionKinesiologyIntact HeartConstitutive DescriptionBiomechanicsApplied PhysiologyCardiologyCardiac MechanicHealth SciencesMechanobiologyContracting Papillary MusclePhysiologyCardiac HealthCardiovascular PhysiologyMedicineAnesthesiology
A simple mathematical model capable of simulating the major biomechanical attributes of contracting cardiac muscle is presented. This model is based on the phenomenological observations on heart muscle. The form of the equation can be readily extended to describe the pressure-volume-time-velocity of the intact heart as well, thus allowing a direct bridge between the dynamics of papillary muscle and the dynamics of intact heart. Parameters that are sensitive to inotropic state of the muscle can be obtained directly from the isometric tension-time record of the muscle or the isovolumic pressure-time record of the ventricle. These parameters have the potential to serve as quantitative measures of cardiac health.