Palladium-catalyzed direct arylation of polyfluoroarenes with aryl tosylates and mesylates

Abstract

This study reports the first general Pd-catalyzed direct arylation of polyfluoroarenes with aryl tosylates/mesylates. A wide range of polyfluoroarenes can be coupled with both aryl tosylates and mesylates under relatively mild reaction conditions (90 °C, in the presence of a weak base KOAc, without any additional acid additives). Moreover, a one-pot sequential C–H bond functionalization/C–N bond coupling has been successfully accomplished by employing one single Pd/CM-phos catalyst system.