Spatially resolved biosensing with a molded plasmonic crystal

Abstract

The authors report the use of a type of quasi-three-dimensional plasmonic crystal for spatially resolved detection of biochemical binding events, with a spatial resolution of tens of microns and submonolayer binding sensitivity. In demonstration experiments, fibrinogen patterns nonspecifically adsorbed to the crystal surface were spatially and spectroscopically resolved using monochromatic and white light illumination. The experimental simplicity of the fabrication and use of these sensors, their compact form factors together with the high detection sensitivities and spatial resolution that can be achieved, collectively make these devices interesting as candidates for label-free array-based bioanalytical detection.