Publication | Closed Access
THE PERISTALTIC REFLEX IN THE ISOLATED GUINEA‐PIG ILEUM DURING DRUG‐INDUCED SPASM OF THE LONGITUDINAL MUSCLE
22
Citations
0
References
1968
Year
Muscle FunctionGastrointestinal PharmacologyGastroenterologyAnatomyDigestive TractRhythmic LengtheningCircular Muscle ContractionNeuromuscular BlockadeDigestive System SurgeryCircular MuscleKinesiologyBiomechanicsThe Longitudinal MuscleHealth SciencesMechanobiologyAnimal PhysiologyNervous SystemNeuromuscular PhysiologyPhysiologyElectrophysiologyMedicineAnesthesiology
Summary The guinea‐pig isolated ileum, when contracted by various drugs, is known to undergo rhythmic lengthening when peristalsis is induced by distension. The mechanism of this lengthening was examined. Lengthing was always associated with circuler muscle contractios, was not prevented by guanethidine, was not observed in parts of the ileum adjacent to parts undergoing peristalsis and could be produced by contracting the circular muscle in preparations blocked with procaine. When the shortening of the circular muscle was mechanically limited, the lengthening of the longitudinal muscle was decreased. It was concluded that this lengthening is a direct mechanical consequence of circular muscle contraction.