Expression of Hypoxia-inducible Factor-1 and Vascular Endothelial Growth Factor in Response to Venous Hypertension

Abstract

In this model, venous hypertension stimulates angiogenesis by a mechanism other than ischemia. HIF-1 expression may result from dilation of parasagittal veins and endothelial deformation. HIF-1 and VEGF seem to be molecular agents that convert venous hypertension into intracellular signals and angiogenesis activity.