Differentiation of Exudative Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in the<i>ARMS2</i>/<i>HTRA1</i>Locus

Abstract

There is a strong and consistent association of the ARMS2/HTRA1 locus with both exudative AMD and PCV, suggesting the two disorders share, at least partially, similar molecular mechanisms. Different effect sizes indicate the existence of additional genetic and environmental factors affecting them to different extents.