CuCl-catalyzed ortho trifluoromethylation of arenes and heteroarenes with a pivalamido directing group

Abstract

The CuCl catalyzed direct trifluoromethylation of sp(2) C-H bonds has been realized, using the Togni reagent as the CF3 source. This reaction achieves the goal of regio-selectively converting C-H into C-CF3 with ecological and readily available starting materials.