Concepedia

Synthesis of Aromatic Thioamide from Nitrile Without Handling of Gaseous Hydrogen Sulfide

Akira Manaka, Masakazu Sato

Synthetic Communications · 2005 · 57 citations · 11 references

DOI

Concepts

Abstract

Abstract A new method for synthesizing aromatic primary thioamides is described. Simple treatment of aromatic nitriles with sodium hydrogen sulfide and magnesium chloride in dimethylformamide (DMF) gave aromatic primary thioamides in yields of 80–99% without handling of hazardous hydrogen sulfide.

References

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