DESMOPRESSIN IMPAIRS MICROCIRCULATION IN DONOR PANCREAS AND EARLY GRAFT FUNCTION AFTER EXPERIMENTAL PANCREAS TRANSPLANTATION

Abstract

Repeated application of desmopressin impairs graft microcirculation. Perfusion of the pancreas is significantly reduced at the beginning of organ tissue conservation as well as after reperfusion. These disturbances might partly be due to observed endothelial P-selectin expression. Application of desmopressin up to 12 hr prior to organ explantation may impact graft quality.