<i>N</i>,<i>N</i>′-Dioxide−Cu(OTf)₂ Complex Catalyzed Highly Enantioselective Amination Reaction of <i>N</i>-Acetyl Enamide

Abstract

The N,N'-dioxide-Cu(OTf)(2) complexes were applied in the asymmetric amination reaction of N-acetyl enamides with dialkyl azodicarboxylate, giving the corresponding products in good yields with high enantioselectivities (up to 91% ee). Precursors of vicinal diamine were readily obtained with excellent diastereoselectivities (>95:5) by NaBH(4) reduction.