Tissue Antigens · 2001 · 78 citations · 4 references
Life SciencesGeneticsMolecular GeneticsHuman GeneticsImmunogeneticsMedical GeneticsAnkylosing SpondylitisGenetic Diversity AssessmentHla TypingMolecular TypingPopulation ImmunogeneticsHla Allele Frequency DistributionHla Allele PolymorphismHla DiversityHla Genotype AssociationsHla Polymorphism AnalysisHla Risk AllelesHuman Leukocyte Antigen B27Polymerase Chain Reaction Hla Typing
A polymerase chain reaction-sequence-specific primer (PCR-SSP) method which distinguishes all B27 alleles described at present (B*2701-23) has been developed. The distribution of B27 alleles was characterised in six different Asian populations. HLA-B*2705, 02, 04, 07, 22 (formerly B*2706) subtypes found in Asian populations differ in their ethnic distribution, which may be the result of different genetic and geographic origins. Furthermore, two novel B27 alleles were found in this study. B*2714 was identified in two Siberians, one of whom was a patient with ankylosing spondylitis. B*2715 was found in two patients with ankylosing spondylitis in Thais. These associations have not previously been reported in either ethnic group.
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Nomenclature for factors of the hla system, 2000
Steven G. E. Marsh, J. G. Bodmer, Walter F. Bodmer et al. · Human Immunology · 2001 · 141 citations
Life Sciences, Genetics, Immunology +11