Strategy for the Synthesis of Pyrimidine Derivatives: NbCl₅-Mediated Cycloaddition of Alkynes and Nitriles

Abstract

Intermolecular cycloadditions of alkynes (terminal alkynes and internal alkynes) with aryl nitriles were successfully achieved, using an NbCl5 complex, to give substituted pyrimidine derivatives in high yields with excellent chemo- and regioselectivity.