Chemical and Pharmaceutical Bulletin · 1997 · 50 citations · 1 references
MedicineDermatologyPharmacologyAllergyHypersensitivityInflammationAnti-inflammatory PharmacologyInflammation PharmacologyInflammatory DermatosesInflammatory Skin DiseasesInflammatory Skin DisordersSkin IrritationAnti-inflammatory ActivityAnti-inflammatory Natural ProductsArachidonic Acid MetabolitesChemical-induced DermatitisDermatologic PharmacologyTopical Anti-inflammatory PreparationsTopical Anti-inflammatory TherapyTopical Dermatologic Therapy
The hydroalcoholic extract from P. cocos was examined for oral and topical anti-inflammatory activities. It proved to be active against carrageenan, arachidonic acid, tetradecanoyl phorbol acetate (TPA) acute edemas, TPA chronic inflammation and oxazolone delayed hypersensitivity in mice. Two lanostane-type triterpenes were isolated and identified by spectroscopic methods as dehydrotumulosic and pachymic acids. Their ID50 on acute TPA edema was 4.7 x 10(-3) and 6.8 x 10(-4) mumol/ear, respectively.
1