Two insulin-like peptide family members from the mosquito Aedes aegypti exhibit differential biological and receptor binding activities

An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control

Walter Brogiolo, Hugo Stocker, Tomoatsu Ikeya et al. · Current Biology · 2001 · 1.3K citations · Full text

Life Sciences, Biology, Endocrinology +15

Ablation of Insulin-Producing Neurons in Flies: Growth and Diabetic Phenotypes

Eric Rulifson, Seung K. Kim, Roel Nusse · Science · 2002 · 1.1K citations

Life Sciences, Entomology, Neuroscience +17

Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4

Ruth Böhni, Juan R. Riesgo‐Escovar, Sean Oldham et al. · Cell · 1999 · 846 citations · Full text

Life Sciences, Genetics, Molecular Genetics +14

Longer lifespan, altered metabolism, and stress resistance in <i>Drosophila</i> from ablation of cells making insulin-like ligands

Susan Broughton, Matthew D. W. Piper, Tomoatsu Ikeya et al. · Proceedings of the National Academy of Sciences · 2005 · 840 citations · Full text

Life Sciences, Developmental Biology, Entomology +17

Activation of Orphan Receptors by the Hormone Relaxin

Sheau Yu Hsu, Koji Nakabayashi, Shinya Nishi et al. · Science · 2002 · 786 citations

Life Sciences, Endocrinology, Molecular Biology +17