Autophagy · 2011 · 12 citations · 0 references
Life SciencesMicrobiologyMolecular BiologyAutophagyInnate ImmunitySignal TransductionAutophagy In ImmunityAutophagy In Stress ResponsesAutophagy ModulationAutophagy RegulationAutophagy Signaling PathwaysAutophagy In Bacterial InfectionAutophagy PathwayAutophagy-mediated ImmunityInfection-induced AutophagyLipid Signaling In AutophagyPathogen-targeted AutophagyPathogen-triggered AutophagyPhagocyte-autophagy Interactions
Antibacterial autophagy is understood to be a key cellular immune response to invading microbes. However, the mechanism(s) by which bacteria are selected as targets of autophagy remain unclear. We recently identified diacylglycerol as a novel signaling molecule that targets bacteria to the autophagy pathway, and show that it acts via protein kinase C activation. We also found that Pkc1 is required for autophagy in yeast, indicating that this kinase plays a conserved role in autophagy regulation.