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A General Copper-Catalyzed Coupling of Azoles with Vinyl Bromides
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2009
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Materials ScienceChemical EngineeringCross-coupling ReactionEngineeringNovel OrganocatalystsCopper-catalyzed MethodologyVarious AzolesOrganic ChemistryOrganometallic CatalysisCatalysisChemistrySynthesis MethodAsymmetric CatalysisVinyl Bromides
A copper-catalyzed methodology for the coupling of vinyl bromides with azoles has been developed. This protocol uses a combination of 10 mol % of copper iodide and 20 mol % of ethylenediamine as catalyst. The reaction proceeds with various azoles and vinyl bromides, and the double bond geometry of vinyl bromides is retained under the reaction conditions.