Effects of Theophylline on Radioiodide Uptake in MCF-7 Breast Cancer and NIS Gene–Transduced SNU-C5 Colon Cancer Cells

Abstract

Theophylline can augment radioiodide uptake in breast cancer cells and NIS gene-transduced cancer cells through the upregulation of NIS expression. Therefore, further investigations are warranted to explore the potential utility of this phenomenon for enhancing radioiodide-based imaging and therapies of NIS gene-transduced cancer cells.