Decreased <i>S</i> -Nitrosylation of Tissue Transglutaminase Contributes to Age-Related Increases in Vascular Stiffness

Abstract

Decreased S-nitrosylation of TG2 and increased TG activity lead to enhanced matrix crosslinking and contribute to vascular stiffening in aging. TG2 appears to be the member of the transglutaminase family primarily contributing to this phenotype. Inhibition of TG2 could thus represent a therapeutic target for age-associated vascular stiffness and isolated systolic hypertension.