Electroretinographic Responses to Alternating Gratings Before and After Section of the Optic Nerve

Abstract

Electroretinographic (ERG) responses to sinusoidal gratings reversed in contrast (pattern-reversal ERG) were recorded from both eyes of cats before and after unilateral section of the optic nerve. In the eye ipsilateral to the section, the pattern-reversal ERG remained unaltered for a few days after the section, the progressively decreased in amplitude, first at low and then at high spatial frequencies, to disappear completely about 4 months after the section, when ganglion cell degeneration was practically complete. The flash ERG remained unaltered. No alteration was observed in the contralateral eye.