DNA double-strand breaks induced by decay of¹²³I-labeled Hoechst 33342: Role of DNA topology

Abstract

(123)IEH-induced DSB yield for SC but not L DNA is consistent with the dosimetric expectations for Auger electron emitters. These studies highlight the role of DNA topology in DSB production by Auger emitters and underscore the failure of current theoretical dosimetric methods per se to predict the magnitude of DSB.