Tissue-Engineered Cultured Periosteum Sheet Application to Treat Infrabony Defects: Case Series and 5-Year Results

Abstract

Kazuhiro Okuda, DDS, PhD/Tomoyuki Kawase, DDS, PhD/Masaki Nagata, DDS, PhD/Kanoko Yamamiya, DDS, PhD/Koh Nakata, MD, PhD/Larry F. Wolff, MS, PhD, DDS/Hiromasa Yoshie, DDS, PhD: One-year data after autologous grafting of infrabony periodontal defects with human cultured periosteum sheets in combination with platelet-rich plasma and hydroxyapatite granules have shown favorable clinical and radiographic results. A 5-year follow-up evaluation of 22 selected patients indicated that treated infrabony defects remained stable. Radiographically, there was an increase in osseous radiopacity and bone trabeculation suggesting further bone maturation. This novel tissue-engineered periodontal treatment approach has resulted in significant clinical improvement, and defects remained stable after 5 years. (Int J Periodontics Restorative Dent 2013;33:281–287. doi: 10.11607/prd.1545)