PHENOTYPE AND LOCALIZATION OF MACROPHAGES EXPRESSING INDUCIBLE NITRIC OXIDE SYNTHASE IN RAT HEPATIC ALLOGRAFT REJECTION

Abstract

These results suggest that the intense iNOS expression by the monocyte/macrophage lineage among the hepatic infiltrates and by the splenic macrophages after transplantation supports a role for nitric oxide in the immunomodulation of allogeneic responses in local and remote organs, and possibly serves as a mediator of cytotoxic graft damage.