Publication | Closed Access
Synthesis of selectively trifluoromethylated pyridine derivaties as potential antihypertensives
31
Citations
5
References
1988
Year
Medicinal ChemistryDerivative (Chemistry)Natural SciencesDiversity-oriented SynthesisFluorous SynthesisOrganic ChemistryNew Cf 3Potassium‐channel Openers 2AChemistryPyridine DerivatiesGeneral SynthesisPharmacologyHeterocycle ChemistryPharmaceutical ChemistrySynthetic Chemistry
Abstract A general synthesis of selectively 6‐(trifluoromethyl)‐substitued 2(1 H )‐pyridinones is described. Further transformation of one of these compounds leads to the new CF 3 ‐containing potassium‐channel openers 2a and 2b .
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