Isocyanide-Based Two-Step Three-Component Keteneimine Formation

Abstract

The addition of isocyanides to acyl chlorides (Isocyanide-Nef reaction) leads to imidoyl chlorides which can later be treated with trialkylphosphites to afford new keteneimines in a Perkow-type reaction. The whole sequence may be performed without any solvent, and the resulting keteneimine may easily be converted to phosphorylated tetrazoles and triazoles.